How a single amino acid substitution transforms BRAF from a regulated kinase into a constitutively active oncogenic driver through phospho-mimetic activation.

How LKB1 loss creates dependency on HDAC6 deacetylase activity, revealing a precision medicine opportunity in lung adenocarcinoma through microtubule dynamics.

From single disease to molecular taxonomy—how CRC classification transformed from histology to genomics, enabling precision medicine for 153,000 annual diagnoses.